Event Date
SPEAKER: Javier Arsuaga; Professor, Mathematics / Molecular & Cellular Biology, UC Davis
TITLE: “Statistical topology in the Analysis of Chromosome Conformation Capture Data”
ABSTRACT: Chromosome Conformation Capture (CCC) has revolutionized chromosome biology by uncovering information of the 3D genome that was completely inaccessible by previous experimental techniques. The data obtained in a CCC experiment, contact probabilities between different loci of the genome, are estimations of a true underlying distance map between the genomic loci. In this work we first show that the fractal model for mammalian 3D organization is one of many models that are in agreement with CCC data, next we discuss the problem of reproducibility and discuss statistical measures that may help determine whether two reconstructions are equivalent or not. This analysis leads us to the introduction of topological measures, which also suggest that the topology of genomes is simpler than what random models would predict.
SPEAKER'S WEB PAGE: https://arsuaga-vazquez-lab.faculty.ucdavis.edu/
DATE: Thursday, March 14th, 4:10pm
LOCATION: MSB 1147, Colloquium Room
REFRESHMENTS: 3:30pm MSB 4110 (4th floor lounge)
STA 290 Seminar List: https://statistics.ucdavis.edu/seminars